Development of Sustained Release Capsules Containing “Coated Matrix Granules of Metoprolol Tartrate”

In vitro In vivo correlation of sustained release capsules of Metoprolol

ISSN:0976-9374 In vitro in vivo correlation of metoprolol tartrate sustained release capsules were studied in this investigation. The half-life of metoprolol is 3 to 4 hours. Peak plasma concentrations vary widely and occur about 1.5 to 2 hours after a single oral dose. In this study, non pareil seeds were prepared and coated with metoprolol tartrate using polyvinyl pyrollidone and iso propyl a...

Formulation and Evaluation of Sustained Release Matrix Tablets of Glipizide

      The purpose of this study was to develop a new monolithic matrix tablet to completely deliver glipizide in a zero order manner over a sustained period. Two approaches were examined using drug in a formulation that contain polymer like hydroxylpropyl methyl-cellulose K 100 (HPMCK) and Eudragit L 100. The granules were prepared by wet granulation method and thereby formulated as F-1, F-2. F...

Asasantin Sr Sustained-release Capsules

Asasantin Sr Sustained-release Capsules

Lopressor® metoprolol tartrate tablets, USP, metoprolol tartrate injection, USP

Lopressor, metoprolol tartrate USP, is a selective beta1-adrenoreceptor blocking agent, available as 50and 100-mg tablets for oral administration and in 5-mL ampuls for intravenous administration. Each ampul contains a sterile solution of metoprolol tartrate USP, 5 mg, and sodium chloride USP, 45 mg, and water for injection USP. Metoprolol tartrate USP is (±)-1­ (Isopropylamino)-3-[p-(2-methoxy...